解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The aim of the study was to evaluate the relationship between phytosterols, oxyphytosterols, and other markers of cholesterol metabolism and concomitant coronary artery disease (CAD) in patients with severe aortic stenosis who were scheduled for elective aortic valve replacement. Markers of cholesterol metabolism (pla...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2015.03.011
更新日期:2015-07-01 00:00:00
abstract::Estrogen is the key regulator of bone metabolism in both men and women. Menopause and the accompanying loss of ovarian estrogens are associated with declines in bone mineral density (BMD): 10-year cumulative loss was 9.1% at the femoral neck and 10.6%, lumbar spine. Estradiol concentrations also predict fractures. Tot...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2014.12.010
更新日期:2015-07-01 00:00:00
abstract::In demyelinating or non-demyelinating neurodegenerative diseases, increased levels of 7-ketocholesterol (7KC), 7β-hydroxycholesterol (7β-OHC) and 24(S)-hydroxycholesterol (24S-OHC) can be observed in brain lesions. In 158N murine oligodendrocytes, 7KC triggers a complex mode of cell death defined as oxiapoptophagy, in...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2015.02.003
更新日期:2015-07-01 00:00:00
abstract::Spinasterol and schottenol, two phytosterols present in argan oil and in cactus pear seed oil, were synthesized from commercially available stigmasterol by a four steps reactions. In addition, the effects of these phytosterols on cell growth and mitochondrial activity were evaluated on 158N murine oligodendrocytes, C6...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2015.01.005
更新日期:2015-07-01 00:00:00
abstract::Brassinosteroids (BRs) are an important class of plant hormones with a multitude of functions. They have been intensively investigated for their biosynthesis, distribution and physiological functions. The aim of this study was to examine possible effects of BRs on the plant plasma membrane cation conductances and Ca(2...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2014.10.008
更新日期:2015-05-01 00:00:00
abstract::Deltonin is a steroidal saponin which could suppress tumor growth through suppressing angiogenesis, but the mechanisms have not been directly elucidated yet. In the present study, we showed that deltonin inhibited the proliferation of primary cultured human umbilical vein endothelial cells (HUVECs) in vitro; notably, ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2014.12.019
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:A high-throughput, sensitive, specific, mass spectrometry-based method for quantitating estrone (E1), estradiol (E2), and testosterone (T) in postmenopausal human serum has been developed for clinical research. The method consumes 100μl human serum for each measurement (triplicates consume 300μl) and does no...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2015.01.007
更新日期:2015-04-01 00:00:00
abstract::Steroid hormone is extensively used for transmitting variety of biological signals in organisms. Natural steroid hormone is synthesized from cholesterol in adrenal cortex and in sexual gland in vertebrates. Appropriately dosed synthetic steroid hormones can be used for medication. Despite their positive effects as med...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2015.01.015
更新日期:2015-04-01 00:00:00
abstract::Dioscorea panthaica is a traditional Chinese medicinal herb used in the treatment of various physiological conditions, including cardiovascular disease, gastropathy and hypertension. Steroidal saponins (SS) are the main active ingredients of this herb and have effects on myocardial ischemia and cancer. The phytochemic...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2014.12.023
更新日期:2015-03-01 00:00:00
abstract::Based on the fact that timosaponin A-III (TA-III) exhibits potent cytotoxic effects and has been considered as a potential anti-tumor agent, a range of novel sarsasapogenin derivatives 1, 2a-2g, 3, 4, 5, 6a-6g have been synthesized by a simple and facile synthetic route. The in vitro cytotoxic activity of these synthe...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2014.09.007
更新日期:2015-01-01 00:00:00
abstract::Ischemic heart disease (IHD) continues to be the most common cause of death globally, although mortality rates are decreasing with significant advances in treatment. Higher prevalence of co-morbidities in women only partly explains the lack of decrease in mortality rates in younger women due to. Until recently there h...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2014.08.013
更新日期:2014-12-01 00:00:00
abstract::Androgens including testosterone and dihydrotestosterone play important roles on brain structure and function, either directly through androgen receptor or indirectly through estrogen receptors, which need coactivators for their transcription activation. Steroid receptor coactivator-1 (SRC-1) has been shown to be mult...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2014.06.006
更新日期:2014-10-01 00:00:00
abstract::Traditional interpretation of GC-MS output involved the semi-quantitative estimation of outstanding low or high specific metabolites and the ratio between metabolites. Here, we utilize a systems biology approach to steroid metabolomics of a complex steroid-related disorder, using an all-inclusive analysis of the stero...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2014.07.003
更新日期:2014-10-01 00:00:00
abstract:INTRODUCTION:ERα36 is a recently cloned variant of estrogen receptor-alpha which has been proved to play an active role in a series of malignant diseases. METHOD:ERα36 expression was examined using immunohistochemical methods with sections from 126 resected NSCLC specimens. The immunoreactivity of ERα66 was also studi...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2014.05.021
更新日期:2014-09-01 00:00:00
abstract::Recent reports demonstrate neurotrophic properties of dehydroepiandrosterone sulfate (DHEAS) in men at rest, as well as profound neurotrophic responses to stress in both men and women. Little is known of neuroprotective-neurotrophic effects of DHEAS during stress exposure, either in men or women. This translational st...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2014.05.011
更新日期:2014-09-01 00:00:00
abstract::Bile acid salts are biosurfactants which form mixed micelles with phospholipids in vertebrates. These mixed micelles are suitable for solubilisation of cholesterol. For therapeutic purposes some bile acid salts as sodium ursocholate are used. However, bile acid anions possess low capacity for solubilisation of cholest...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2014.04.018
更新日期:2014-08-01 00:00:00
abstract::Novel C6-cyclo secondary amine substituted purine steroid-nucleoside analogues (2-9) were efficiently synthesized through displacement of the C6 chloro on the purine ring of series 1 with versatile cyclic secondary amines, including pyrrolidines, piperidine, morpholine, and piperazines. All the newly-synthesized compo...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2014.03.017
更新日期:2014-07-01 00:00:00
abstract::Glucocorticoids are an important class of anti-inflammatory/immunosuppressive drugs. A crucial part of their anti-inflammatory action results from their ability to repress proinflammatory transcription factors such as nuclear factor-κB (NF-κB) and activator protein-1 (AP-1) upon binding to the glucocorticoid receptor ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2014.04.003
更新日期:2014-07-01 00:00:00
abstract::To reduce the variability in estradiol (E2) testing and to assure better patient care, standardization of E2 measurements has been recommended. This study aims to assess the accuracy and variability of E2 measurements performed by 11 routine immunological methods and 6 mass spectrometry methods using single donor seru...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2013.12.005
更新日期:2014-04-01 00:00:00
abstract::Fermentation of mesterolone (1) with Cunninghamella blakesleeana yielded four new metabolites, 1α-methyl-1β,11β,17β-trihydroxy-5α-androstan-3-one (2), 1α-methyl-7α,11β,17β-trihydroxy-5α-androstan-3-one (3), 1α-methyl-1β,6α,17β-trihydroxy-5α-androstan-3-one (4) and 1α-methyl-1β,11α,17β-trihydroxy-5α-androstan-3-one (5)...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2014.01.001
更新日期:2014-04-01 00:00:00
abstract::Novel C6-piperazine substituted purine nucleoside analogues (2-9) bearing a modified pyranose-like D ring of the 4-azasteroid moiety were efficiently synthesized through nucleophilic substitution at C6 position of the steroid-nucleoside precursors (1) with versatile piperazines. All newly-synthesized compounds were ev...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2013.12.004
更新日期:2014-04-01 00:00:00
abstract::Contrary to the long-held postulate of steroid-hormone binding globulin action, these protein carriers of steroids are major players in steroid actions in the body. This manuscript will focus on our work with sex hormone binding globulin (SHBG) and corticosteroid binding globulin (CBG) and demonstrate how they are act...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2013.11.010
更新日期:2014-03-01 00:00:00
abstract::While the neuroprotective benefits of estrogen and progesterone in critical illness are well established, the data regarding the effects of androgens are conflicting. Surgical repair of congenital heart disease is associated with significant morbidity and mortality, but there are scant data regarding the postoperative...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2013.11.003
更新日期:2014-03-01 00:00:00
abstract::A new synthetic pathway towards secosteroidal macrocycles was described via a reaction of cycloaddition as the key step. The characteristic (1)H and (13)C NMR spectroscopic features of the synthesized compounds are reported. ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2013.12.002
更新日期:2014-02-01 00:00:00
abstract::Data in animal models and surveys in humans have revealed psychiatric complications of long-term anabolic androgenic steroid abuse. However, the neurobiochemical mechanisms behind the observed behavioral changes are poorly understood. The aim of the present study was to investigate the effects of nandrolone decanoate ...
journal_title:Steroids
pub_type: 杂志文章
doi:
更新日期:2014-01-01 00:00:00
abstract::Metandienone is one of the most frequently detected anabolic androgenic steroids in sports drug testing. Metandienone misuse is commonly detected by monitoring different metabolites excreted free or conjugated with glucuronic acid using gas chromatography mass spectrometry (GC-MS) and liquid chromatography tandem mass...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2013.09.005
更新日期:2013-12-11 00:00:00
abstract::Enzyme immunoassays (EIA) are commonly utilized for the evaluation of androgens in biological fluids; however, careful consideration must be given to cross-reactivity with other endogenous sex-steroid hormones. Our purpose was to determine the validity of a commonly-utilized commercially-available dihydrotestosterone ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2013.08.013
更新日期:2013-12-11 00:00:00
abstract::A rapid, simple and sensitive high-performance liquid chromatography tandem mass spectrometry method was developed and validated for simultaneous determination of six main steroidal saponins in Paris polyphylla in rat plasma. Ginsenoside Rg3 was selected as the internal standard (IS). Plasma samples were pretreated wi...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2013.08.009
更新日期:2013-12-11 00:00:00
abstract::Using dehydroepiandrosterone as the starting material, we have synthesized a series of steroid analogs possessing a D-ring fused with heterocycles which are pyridine, imidazo [2,1-b]thiazoles or substituted thiazole imines. All the final structures are first reported and identified by NMR and MS spectroscopys, the yie...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2013.07.006
更新日期:2013-12-11 00:00:00
abstract::The catalytic cycloalumination of 2'-methylidene-2',3'-ethano-(5α)-cholestane with Et3Al catalyzed by Cp2ZrCl2 was performed for the first time to give spiro[2',3'-ethano-(5α)-cholestane-2',3″-aluminacyclopentane] in a ~75% yield and with high stereoselectivity (>98%). The obtained cyclic organoaluminum compound was t...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2013.09.007
更新日期:2013-12-11 00:00:00
abstract::Formestane (F, androst-4-en-4-ol-3,17-dione) is an irreversible aromatase inhibitor with the ability to suppress the estrogen production from anabolic steroids. Consequently, F is mentioned on the World Anti-Doping Agency (WADA) prohibited list and because studies have shown that F is produced endogenously in small am...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2013.07.011
更新日期:2013-11-01 00:00:00
abstract::We developed a sensitive, reliable, and accurate LC/ESI-MS/MS method for measurement of 3β-sulfooxy-7β-N-acetylglucosaminyl-5-cholen-24-oic acid and its glycine and taurine amides in urine. This atypical C24 bile acid has been reported previously to be present in the urine of patients with Niemann-Pick Type C (NPC) di...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2013.05.017
更新日期:2013-10-01 00:00:00
abstract::Ten new 9,11-secosteroids, subergorgols A-J (1-10), including two pairs of epimers (3/4, and 6/7), along with three known analogues (11-13) were isolated from the South China Sea gorgonian Subergorgia suberosa. The structures of these compounds were elucidated on the basis of extensive spectroscopic analyses and compa...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2013.05.009
更新日期:2013-09-01 00:00:00
abstract::Two unnatural steroid sapogenins bearing a furospirostane side chain were prepared starting from the readily available spirostane sapogenins, tigogenin and diosgenin following a synthetic protocol that included: (i) introduction of a carbonyl group at position C-23, (ii) diacetoxyiodobenzene-induced F-ring contraction...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2013.05.013
更新日期:2013-09-01 00:00:00
abstract::Two new 4-methyl-progesteroids, nodulisporisteriod A (1) and nodulisporisteriod B (2), were isolated from the extract of an endolichenic fungal strain Nodulisporium sp. (No. 65-17-2-1), along with two related metabolites, demethoxyviridin (3) and inoterpene B (4). Their structures were determined by detailed spectrosc...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2013.05.007
更新日期:2013-09-01 00:00:00
abstract::Polycystic ovary syndrome (PCOS) is the most common endocrine problem affecting women of reproductive age and is investigated from many regions of the world. Some reports have indicated ethnic difference in its manifestation. This review addressed the evidences for ethnic variation in the expression of PCOS phenotypes...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2013.04.006
更新日期:2013-08-01 00:00:00
abstract::Two variants of the Claisen rearrangement were evaluated for a stereoselective construction of a C-25 stereogenic center in cholestenoic acids based on 1,4-chirality transfer. Johnson orthoester Claisen rearrangement of (22R)- and (22S)-propargyl enol ethers proceeded in a highly stereoselective manner to give (25R)- ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2013.03.006
更新日期:2013-07-01 00:00:00
abstract::Recent studies have suggested that progestins play a role in the etiology of breast cancer; however, the mechanisms by which progestins promote tumor formation/progression have not been defined. Progestin action, in target tissues such as the breast, is mediated by the progesterone receptor (PR). PR signaling is compl...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2012.12.014
更新日期:2013-06-01 00:00:00
abstract::Cell cycle regulator p21(CIP1) has controversial biological effects in breast cancer since in spite of its role as cell cycle inhibitor and promoter of cellular senescence, it also induces cell proliferation and chemoteraphy resistance. We here explored the molecular mechanisms involved in progestin regulation of p21(...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2012.11.003
更新日期:2013-06-01 00:00:00
abstract::A series of final twelve propanoyloxy derivatives of 5β-cholan-24-oic acid (O-propanoyl derivatives of cholic acid) as potential drug absorption modifiers (skin penetration enhancers, intestinal absorption promoters) was generated by multistep synthesis. Structure confirmation of all generated compounds was accomplish...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2013.02.001
更新日期:2013-05-01 00:00:00